3-Nitro-p-cresol → 3-Amino-p-cresol

HRID 67162

반응식

HRID 67162 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([OH:11])[CH:7]=[CH:8][C:9]=1[CH3:10])([O-])=O.[H][H]>[Ni].O1CCCC1>[NH2:1][C:4]1[CH:5]=[C:6]([OH:11])[CH:7]=[CH:8][C:9]=1[CH3:10]

참가 물질

5

반응물 2

HCID 162713-Nitro-p-cresolHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 178203-Amino-p-cresol

시약·촉매·용매 2

HCID 935Nickel촉매HCID 8028Tetrahydrofuran용매

실험 절차

70 g of 3-nitro-4-methylphenol, prepared according to German Offenalegungschrift No. 2,213,568, 200 ml of tetrahydrofuran and 2 g of activated Raney nickel catalyst were placed in a Parr bomb. The mixture was shaken for 3.5 hours under 60 p.s.i. hydrogen pressure. The mixture then was filtered and the solvent was evaporated from the filtrate. The residue was recrystallized from ether to give 3-amino-4-methylphenol (3A), as a grey solid, mp: 145°-148° C.

후처리

  1. filtrationThe mixture then was filtered
  2. customthe solvent was evaporated from the filtrate
  3. customThe residue was recrystallized from ether

출처 및 근거

ORD 기록
ord-2a417ce8477b47ffb0400faad8e9f2d7
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04345077

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