3-Hydroxy-2-naphthoic acid → 6-Hydroxy-2-naphthoic acid

반응식

[K].[OH:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=1.OC1C([C:24]([OH:26])=[O:25])=CC2C(C=1)=CC=CC=2>>[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C:24]([OH:26])=[O:25])[CH:7]=[CH:6]2

참가 물질

반응물 3

HCID 71043-Hydroxy-2-naphthoic acid

HCID 86632-Naphthol

HCID 5462222Potassium

생성물 1

HCID 855576-Hydroxy-2-naphthoic acid

실험 절차

In the carboxylation of the potassium salt of 2-hydroxynaphthalene, the initial product form is 3-hydroxy-2-naphthoic acid which subsequently rearranges in situ to form 6-hydroxy-2-naphthoic acid. It has been found that the conditions which favor the formation of 3-hydroxy-2-naphthoic acid in the Kolbe-Schmitt reaction hinder the rearrangement reaction.

출처 및 근거

ORD 기록: ord-ea8f95bbc1594355b96abb88c08757be
출처 데이터셋: uspto-grants-1982_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04345095

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