Nonanoyl chloride → N,N-bis(Pelargonoyloxyethyl)pelargonoylacetamide

HRID 67286

반응식

HRID 67286 반응식
[C:1](Cl)(=[O:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[OH:12][CH2:13][CH2:14][N:15]([CH2:20][CH2:21][OH:22])[C:16](=[O:19])[CH2:17]O>N1C=CC=CC=1>[C:1]([O:22][CH2:21][CH2:20][N:15]([CH2:14][CH2:13][O:12][C:1](=[O:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9])[C:16](=[O:19])[CH2:17][C:1](=[O:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9])(=[O:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

참가 물질

4

반응물 2

HCID 69819Nonanoyl chlorideHCID 87097N,N-Bis(2-hydroxyethyl)glycolamide

생성물 1

HCID 86738544N,N-bis(Pelargonoyloxyethyl)pelargonoylacetamide

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

106 g (0.6 mole) of pelargonoyl chloride was added dropwise with stirring to a solution of 32.6 g (0.2 mole) of N,N-bis(hydroxyethyl)hydroxyacetamide in 60 ml of pyridine. The precipitated pyridine hydrochloride was filtered, washed with benzene, and discarded. The benzene solution of product was water washed, dried over sodium sulfate, and passed through an activated alumina column to remove any acid. The benzene was stripped off an a rotary evaporator. The yield of product was essentially quantitative. Its structure was established by infrared and nuclear magnetic resonance spectroscopy. It had nD30 1.4537 and d430 0.9745.

후처리

  1. filtrationThe precipitated pyridine hydrochloride was filtered
  2. washwashed with benzene
  3. washwashed
  4. dry with materialdried over sodium sulfate
  5. customto remove any acid
  6. customa rotary evaporator

출처 및 근거

ORD 기록
ord-f0ca0e9fafa44133964a201cb876e151
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04346043

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