Acetic Acid → (5-methoxy-4-methyl-1H-indol-3-ylmethyl)dimethylamine

HRID 6744

반응식

HRID 6744 반응식
[C:1](O)(=O)C.[CH3:5][NH:6][CH3:7].C=O.[CH3:10][O:11][C:12]1[C:13]([CH3:21])=[C:14]2[C:18](=[CH:19][CH:20]=1)[NH:17][CH:16]=[CH:15]2>C(O)C>[CH3:10][O:11][C:12]1[C:13]([CH3:21])=[C:14]2[C:7](=[CH:19][CH:20]=1)[NH:6][CH:5]=[C:15]2[CH2:16][N:17]([CH3:1])[CH3:18]

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 674DimethylamineHCID 712FormaldehydeHCID 32962425-Methoxy-4-methylindole

생성물 1

HCID 22018474(5-methoxy-4-methyl-1H-indol-3-ylmethyl)dimethylamine

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

Acetic acid (0.39 mL) and dimethylamine (0.85 mL of a 40% aqueous solution) were added to a suspension of paraformaldehyde (0.21 g) in 25 mL ethanol. The mixture was heated to reflux until it was clear. The solution was cooled to rt and a solution of 5-methoxy-4-methyl-indole (1.0 g) in 25 mL of ethanol was added. The reaction was heated to reflux for 3 h. The volatiles were removed in vacuo to yield (5-methoxy-4-methyl-1H-indol-3-ylmethyl)-dimethylamine (1.0 g).

후처리

  1. temperatureThe mixture was heated
  2. temperatureto reflux until it
  3. temperatureThe reaction was heated
  4. temperatureto reflux for 3 h
  5. customThe volatiles were removed in vacuo

출처 및 근거

ORD 기록
ord-cb0d67a099774221b16872d3e7d1a7ba
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084154B2

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