Ammonium Hydroxide → 2-Amino-3-chlorobenzoic acid

HRID 67895

반응식

HRID 67895 반응식
S(S([O-])=O)([O-])=O.[Na+].[Na+].[Cl:9][C:10]1[C:11]([N+:19]([O-])=O)=[C:12]([CH:16]=[CH:17][CH:18]=1)[C:13]([OH:15])=[O:14].[OH-].[NH4+]>O>[Cl:9][C:10]1[C:11]([NH2:19])=[C:12]([CH:16]=[CH:17][CH:18]=1)[C:13]([OH:15])=[O:14]

참가 물질

5

반응물 3

HCID 14923Ammonium HydroxideHCID 209023-Chloro-2-nitrobenzoic acidHCID 24489Sodium Dithionite

생성물 1

HCID 808072-Amino-3-chlorobenzoic acid

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

Sodium dithionite (104.4 g, 0.6 m) in water (400 ml) was added in portions to a slurry of 3-chloro-2-nitrobenzoic acid (30 g, 0.15 m) in water (200 ml) containing concentrated ammonium hydroxide solution (10 ml). After stirring an additional 20 minutes the mixture was filtered, acidified to pH 3-4 with concentrated hydrochloric acid and filtered again. The filtrate was saturated with sodium chloride and extracted with ether. Drying and concentration of the extract gave a white powder which was combined with the precipitates above. The crude product was used without further purification.

후처리

  1. filtrationwas filtered
  2. filtrationfiltered again
  3. extractionextracted with ether
  4. customDrying
  5. customconcentration of the extract gave a white powder which
  6. customprecipitates above
  7. customThe crude product was used without further purification

출처 및 근거

ORD 기록
ord-706f0b1f994f43288963165420bbb526
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04347246

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