Acetic Anhydride → N-[1-(6-Chloro-2-pyridyl)-2-pyrazolin-3-yl]formamide

HRID 67904노트

반응식

HRID 67904 반응식
[Cl:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:12][CH2:11][C:10]([NH:13][C:14](=[O:16])C)=[N:9]2)[CH:5]=[CH:4][CH:3]=1.C(OC(=O)C)(=O)C>C(O)=O>[Cl:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:12][CH2:11][C:10]([NH:13][CH:14]=[O:16])=[N:9]2)[CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 13050983N-[1-(6-Chloro-2-pyridyl)-2-pyrazolin-3-yl]acetamide

생성물 1

HCID 13050984N-[1-(6-Chloro-2-pyridyl)-2-pyrazolin-3-yl]formamide

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

A mixture of 5.0 g. of 2-(3-amino-2-pyrazolin-1-yl)-6-chloropyridine (prepared as described in Example 3) and 25 ml. of a mixture of formic acid and acetic anhydride (Feiser and Feiser, Reagents for Organic Synthesis, Vol. 1, page 4) at room temperature gives an immediate yellow precipitate. The precipitate is collected by filtration then is recrystallized from acetone-hexane to give 3.05 g. of the product of the Example as off-white crystals, m.p. 190°-192° C.

후처리

  1. additionA mixture of 5.0 g
  2. customgives an immediate yellow precipitate
  3. filtrationThe precipitate is collected by filtration
  4. customthen is recrystallized from acetone-hexane
  5. customto give 3.05 g

출처 및 근거

ORD 기록
ord-b3c9d641736e4e999de7ec8af81e9585
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04347251

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