Diethyl Ether → Ethyl dodecane hydroximate

HRID 67945

반응식

HRID 67945 반응식
[Cl-].O[NH3+].CC[O:6]CC.[CH2:9]([O:11][C:12](=[NH:24])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH3:10]>O>[C:12](=[N:24][OH:6])([O:11][CH2:9][CH3:10])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23]

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 21645Hydroxylamine HClHCID 3442835Ethyldodecaneimidate

생성물 1

HCID 86738559Ethyl dodecane hydroximate수율 77%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
2 °C

실험 절차

A mixture containing fourteen grams of hydroxylammonium chloride dissolved in 100 ml of water was added to 100 ml of ether in a 250 ml flask. The resulting mixture was cooled to 2° C. and 45.4 g of ethyldodecaneimidate were added to the mixture with stirring. The reaction mixture was stirred for an additional 30 minutes at 2° C. The layers were separated and the aqueous layer was extracted three times with 75 ml of ether. The ether layer and washings were combined and then dried over sodium sulfate and concentrated to yield 37.3 g (77% yield) of ethyl dodecane hydroximate as a white, solid substance. IR and NMR analyses confirmed the structure.

후처리

  1. stirringThe reaction mixture was stirred for an additional 30 minutes at 2° C
  2. customThe layers were separated
  3. extractionthe aqueous layer was extracted three times with 75 ml of ether
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-e15a47277379479ea60e7f0627918e63
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04347342

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