1,4-Dichlorobenzene → 2-Bromo-1,4-dichlorobenzene

HRID 68021

반응식

HRID 68021 반응식
[Cl-].[Al+3].[Cl-].[Cl-].[Br:5]C1C=CC=CC=1.[CH:12]1[C:17]([Cl:18])=[CH:16][CH:15]=[C:14]([Cl:19])[CH:13]=1.[Br:20][C:21]1[CH:26]=[CH:25][C:24]([Cl:27])=[C:23]([Cl:28])[C:22]=1[Br:29]>[Fe]>[Br:29][C:22]1[CH:21]=[CH:26][C:25]([Cl:18])=[CH:24][C:23]=1[Cl:28].[Br:5][C:15]1[CH:16]=[C:17]([Cl:18])[CH:12]=[CH:13][C:14]=1[Cl:19].[Br:20][C:21]1[CH:26]=[CH:25][C:24]([Cl:27])=[C:23]([Cl:28])[CH:22]=1

참가 물질

8

반응물 4

HCID 46851,4-DichlorobenzeneHCID 7961BromobenzeneHCID 6451240Aluminum(III) ChlorideHCID 140296631,2-dibromo-3,4-dichlorobenzene

생성물 3

HCID 150332-Bromo-1,4-dichlorobenzeneHCID 290134-Bromo-1,2-dichlorobenzeneHCID 709471-Bromo-2,4-dichlorobenzene

시약·촉매·용매 1

HCID 23925Iron촉매

실험 절차

The o-, m- or p-dichlorobenzenes or mixture thereof which is used as intermediates for syntheses of various organic compounds is brominated at 0° to 100° C. in the presence of aluminum chloride, ferric chloride or iron powder. The bromobenzene is chlorinated in the same condition. The dichlorobenzene is reacted with the dibromodichlorobenzene in the presence of an aluminum halide for 1 to 5 hours. In these methods, 1-bromo-2,4-dichlorobenzene, 1-bromo-2,5-dichlorobenzene, and 1-bromo-3,4-dichlorobenzene etc. can be obtained in high yield.

출처 및 근거

ORD 기록
ord-12b808519d014a45884e6fff12f972d8
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04347390

연결된 노트

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