Triethylamine → 4-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, methyl ester

HRID 6811

반응식

HRID 6811 반응식
I[C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].C/[C:10](/[C:16]([O-:18])=[O:17])=[C:11](\C)/[C:12]([O-:14])=O.[CH2:19](N(CC)CC)C>C([O-])(=O)C.C([O-])(=O)C.[Pd+2].C(#N)C>[O:14]=[C:12]1[CH:11]=[C:10]([C:16]([O:18][CH3:19])=[O:17])[C:2]2[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:4]1

참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 119952-IodoanilineHCID 5459894Dimethylmaleate

생성물 1

HCID 1816364-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, methyl ester

시약·촉매·용매 2

HCID 167845palladium(II) acetate촉매HCID 6342Acetonitrile용매

실험 절차

In a heavy-walled PYREX tube was placed 2-iodoaniline (2.84 g, 13 mmol), dimethylmaleate (2.44 g, 17 mmol), triethylamine (1.4 mL, 10 mmol), palladium diacetate (31 mg, 0.14 mmol) and 6 mL acetonitrile. The tube was flushed with nitrogen and sealed. The sealed tube was heated at 100° for 3.5 h then cooled to r.t. The tube was opened and the resulting solids filtered and washed with acetonitrile. The solids were dissolved in chloroform and the solvent removed under vacuum to provide a solid.

후처리

  1. customThe tube was flushed with nitrogen
  2. customsealed
  3. temperatureThe sealed tube was heated at 100° for 3.5 h
  4. filtrationthe resulting solids filtered
  5. washwashed with acetonitrile
  6. dissolutionThe solids were dissolved in chloroform
  7. customthe solvent removed under vacuum
  8. customto provide a solid

출처 및 근거

ORD 기록
ord-ce024ddd171d42738801fd911c4752bb
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084156B2

연결된 노트

불러오는 중…