Iodine → 6-Iodo-3,4-dihydroquinolin-2(1H)-one

HRID 6812

반응식

HRID 6812 반응식
[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C:2]1=[O:11].[I:12]I>C(O)C.S([O-])([O-])(=O)=O.[Ag+].[Ag+]>[I:12][C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[NH:1][C:2](=[O:11])[CH2:3][CH2:4]2

참가 물질

5

반응물 2

HCID 807IodineHCID 64796Hydrocarbostyril

생성물 1

HCID 220189516-Iodo-3,4-dihydroquinolin-2(1H)-one

시약·촉매·용매 2

HCID 159865Silver sulfate촉매HCID 702Ethanol용매2회

실험 절차

3,4-Dihydroquinolin-2(1H)-one (7.5 g; 51 mmol) and silver (I) sulfate (17.5 g; 56.1 mmol) were suspended in ethanol (250 mL). A solution of iodine in ethanol (250 mL) was added slowly to the reaction over 1 hour. After 6 hours, the reaction was filtered through CELITE diatomaceous earth and washed copiously with methanol. The volatiles were removed under vacuum and the crude residue was triturated with ether. The solids were collected on a fritted funnel and dried under vacuum. This provided the title compound.

후처리

  1. filtrationthe reaction was filtered through CELITE diatomaceous earth
  2. washwashed copiously with methanol
  3. customThe volatiles were removed under vacuum
  4. customthe crude residue was triturated with ether
  5. customThe solids were collected on a fritted funnel
  6. customdried under vacuum

출처 및 근거

ORD 기록
ord-d57d16896f9f4187ad5a58a2a543f654
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084156B2

연결된 노트

불러오는 중…