Iodine → 6-Iodo-3,4-dihydroquinolin-2(1H)-one
반응식
[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C:2]1=[O:11].[I:12]I>C(O)C.S([O-])([O-])(=O)=O.[Ag+].[Ag+]>[I:12][C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[NH:1][C:2](=[O:11])[CH2:3][CH2:4]2참가 물질
5
실험 절차
3,4-Dihydroquinolin-2(1H)-one (7.5 g; 51 mmol) and silver (I) sulfate (17.5 g; 56.1 mmol) were suspended in ethanol (250 mL). A solution of iodine in ethanol (250 mL) was added slowly to the reaction over 1 hour. After 6 hours, the reaction was filtered through CELITE diatomaceous earth and washed copiously with methanol. The volatiles were removed under vacuum and the crude residue was triturated with ether. The solids were collected on a fritted funnel and dried under vacuum. This provided the title compound.
후처리
- filtrationthe reaction was filtered through CELITE diatomaceous earth
- washwashed copiously with methanol
- customThe volatiles were removed under vacuum
- customthe crude residue was triturated with ether
- customThe solids were collected on a fritted funnel
- customdried under vacuum
출처 및 근거
- ORD 기록
- ord-d57d16896f9f4187ad5a58a2a543f654
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07084156B2
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