Mannitol → Morphine

반응식

O.O.O.O.O.S(O)(O)(=O)=O.[CH:11]1[C:27]2[CH2:26][C@H:25]3[N:28]([CH2:30][CH2:31][C@@:17]45[C@H:24]3[CH:23]=[CH:22][C@H:20]([OH:21])[C@@H:18]4[O:19][C:15]([C:16]=25)=[C:13]([OH:14])[CH:12]=1)[CH3:29].C(O)[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O>>[CH:11]1[C:27]2[CH2:26][C@H:25]3[N:28]([CH2:30][CH2:31][C@@:17]45[C@H:24]3[CH:23]=[CH:22][C@H:20]([OH:21])[C@@H:18]4[O:19][C:15]([C:16]=25)=[C:13]([OH:14])[CH:12]=1)[CH3:29]

참가 물질

반응물 2

HCID 6251Mannitol

HCID 6436139Sulfuric acid--17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol--water (1/1/5)

생성물 1

HCID 5288826Morphine

실험 절차

The active plug comprised: PoloXamer 188, PEO 300 000, Morphine Sulphate pentahydrate and Mannitol, which were mixed. Afterwards the powder mixture fed to the injection moulding machine.

출처 및 근거

ORD 기록: ord-84cac8d0701c40cc88768422185e2b4c
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08821928B2

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