4,6-Dichloropyrido[3,4-d]pyrimidine → (6-Chloropyrido[3,4-d]pyrimidin-4-yl)-(4-(3-fluorobenzyloxy)-phenyl)-amine

HRID 6829

반응식

HRID 6829 반응식
Cl[C:2]1[C:3]2[CH:11]=[C:10]([Cl:12])[N:9]=[CH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[F:13][C:14]1[CH:15]=[C:16]([CH:26]=[CH:27][CH:28]=1)[CH2:17][O:18][C:19]1[CH:25]=[CH:24][C:22]([NH2:23])=[CH:21][CH:20]=1>C(#N)C>[Cl:12][C:10]1[N:9]=[CH:8][C:4]2[N:5]=[CH:6][N:7]=[C:2]([NH:23][C:22]3[CH:21]=[CH:20][C:19]([O:18][CH2:17][C:16]4[CH:26]=[CH:27][CH:28]=[C:14]([F:13])[CH:15]=4)=[CH:25][CH:24]=3)[C:3]=2[CH:11]=1

참가 물질

4

반응물 2

HCID 108218764,6-Dichloropyrido[3,4-d]pyrimidineHCID 167753144-(3-Fluoro-benzyloxy)-phenylamine

생성물 1

HCID 21952062(6-Chloropyrido[3,4-d]pyrimidin-4-yl)-(4-(3-fluorobenzyloxy)-phenyl)-amine

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

4,6-Dichloro-pyrido[3,4-d]pyrimidine (1 g) and 4-(3-fluorobenzyloxy)aniline (1.08 g) in acetonitrile (70 ml) were reacted together as in Procedure A. The product was collected by filtration as a yellow solid (1.86 g); m/z 381 (M+1)+.

후처리

  1. filtrationThe product was collected by filtration as a yellow solid (1.86 g)

출처 및 근거

ORD 기록
ord-8b3bea1d833140cf9b8c1582932f75e3
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084147B2

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