Dimethylformamide dimethyl acetal → 4-(3-Dimethylamino-acryloyl)-3-methyl-5-methylsulfanylthiophene-2-carbonitrile

HRID 6849

반응식

HRID 6849 반응식
[C:1]([C:4]1[C:5]([CH3:13])=[C:6]([C:11]#[N:12])[S:7][C:8]=1[S:9][CH3:10])(=[O:3])[CH3:2].[CH3:14][N:15]([CH:17](OC)OC)[CH3:16]>C(#N)C>[CH3:14][N:15]([CH3:17])[CH:16]=[CH:2][C:1]([C:4]1[C:5]([CH3:13])=[C:6]([C:11]#[N:12])[S:7][C:8]=1[S:9][CH3:10])=[O:3]

참가 물질

4

반응물 2

HCID 78373Dimethylformamide dimethyl acetalHCID 28201864-Acetyl-3-methyl-5-(methylthio)thiophene-2-carbonitrile

생성물 1

HCID 5360484-(3-Dimethylamino-acryloyl)-3-methyl-5-methylsulfanylthiophene-2-carbonitrile

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a solution of 4-acetyl-3-methyl-5-methylsulfanyl-thiophene-2-carbonitrile (10 mmol) in acetonitrile (5 mL) was added DMF-DMA (2 mL) and the resulting mixture heated at reflux for 18 hours. The reaction was concentrated and the residue triturated with diethyl ether (20 mL). The suspension was filtered and washed with ether to afford the desired product as a yellow solid.

후처리

  1. temperaturethe resulting mixture heated
  2. temperatureat reflux for 18 hours
  3. concentrationThe reaction was concentrated
  4. customthe residue triturated with diethyl ether (20 mL)
  5. filtrationThe suspension was filtered
  6. washwashed with ether

출처 및 근거

ORD 기록
ord-415fb75af4324233a0dbe7387235e9d9
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084159B2

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