4-Nitroanthranilic acid → 4-Nitro-isatoic anhydride
반응식
[NH2:1][C:2]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].N1([C:19](N2C=CN=C2)=[O:20])C=CN=C1>O1CCCC1>[N+:11]([C:9]1[CH:8]=[CH:7][C:3]2[C:4](=[O:6])[O:5][C:19](=[O:20])[NH:1][C:2]=2[CH:10]=1)([O-:13])=[O:12]참가 물질
4
반응 조건
- 온도
- 10 °C
실험 절차
Into a 1000-mL 4-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed a solution of 2-amino-4-nitrobenzoic acid (54.6 g, 300.00 mmol, 1.00 equiv) in tetrahydrofuran (500 mL), di(1H-imidazol-1-yl)methanone (58.32 g, 360.00 mmol). The resulting solution was stirred for 2 h at 10° C. The solids were collected by filtration to yield 7-nitro-1H-benzo[d][1,3]oxazine-2,4-dione as a yellow solid.
후처리
- customInto a 1000-mL 4-necked round-bottom flask purged
- temperaturemaintained with an inert atmosphere of nitrogen
- filtrationThe solids were collected by filtration
출처 및 근거
- ORD 기록
- ord-2a336b5a78e244af99491d07f9fe4946
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08822447B2
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