Acetic Acid → HCID 136386277, 화합물

HRID 68720노트

반응식

HRID 68720 반응식
[NH2:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[C:4]([CH2:13][CH3:14])[C:3]=1[C:15]([NH2:17])=[O:16].N[C:19](N)=[O:20].CC(O)=O>[OH-].[Na+]>[CH2:13]([C:4]1[C:3]2[C:15](=[O:16])[NH:17][C:19](=[O:20])[NH:1][C:2]=2[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=1)[CH3:14]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 1176UreaHCID 540196475-amino-3-ethyl-1-phenyl-1H-pyrazole-4-carboxamide

생성물 1

HCID 136386277HCID 136386277, 화합물

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

반응 조건

온도
200 °C

실험 절차

Into a 100-mL 3-necked round-bottom flask, was placed 5-amino-3-ethyl-1-phenyl-1H-pyrazole-4-carboxamide (1 g, 4.35 mmol, 1.00 equiv) at room temperature. To the resulting mixture was then added urea (1.75 g, 29.17 mmol, 6.70 equiv), in portions at room temperature. The resulting solution was stirred for 1 h at 200° C. The resulting mixture was then cooled to room temperature. The residue was dissolved in sodium hydroxide (250 mL). The pH value of the solution was adjusted to about 5 with AcOH (conc.). The solids were collected by filtration to yield 3-ethyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione as a white solid. MS (m/z): 257 [MH+].

후처리

  1. customInto a 100-mL 3-necked round-bottom flask, was placed
  2. customat room temperature
  3. customat room temperature
  4. temperatureThe resulting mixture was then cooled to room temperature
  5. filtrationThe solids were collected by filtration

출처 및 근거

ORD 기록
ord-4e374c925c824bdca5f708ad3e529ec2
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822447B2

반응 노트

불러오는 중…