Hydrochloric Acid → HCID 178433856, 화합물

HRID 68744노트

반응식

HRID 68744 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:13][C:12]3[N:14]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[N:15]=[C:16]([CH3:17])[C:11]=3[C:10](=[O:24])[CH:9]=2)=[CH:4][CH:3]=1.C(OC([N:32]1[CH2:37][CH2:36][CH:35]([NH2:38])[CH2:34][CH2:33]1)=O)(C)(C)C.Cl>>[CH3:17][C:16]1[C:11]2[C:10]([OH:24])=[CH:9][C:8]([C:5]3[CH:6]=[CH:7][C:2]([NH:38][CH:35]4[CH2:36][CH2:37][NH:32][CH2:33][CH2:34]4)=[CH:3][CH:4]=3)=[N:13][C:12]=2[N:14]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:15]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 12682914-Amino-1-Boc-piperidineHCID 1363862876-(4-bromophenyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-4(7H)-one

생성물 1

HCID 178433856HCID 178433856, 화합물

실험 절차

The title compound was prepared according to the procedure as described in Example 97 reacting via Suzuki coupling of 6-(4-bromo-phenyl)-3-methyl-1-phenyl-1,7-dihydro-pyrazolo[3,4-b]pyridin-4-one and 4-amino-piperidine-1-carboxylic acid tert-butyl ester, followed by de-protection with HCl.

출처 및 근거

ORD 기록
ord-c381c43e202e412bbda4082a627de1e0
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822447B2

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