Hydrochloric Acid → 6-[4-(3,5-Dimethyl-piperazin-1-yl)-phenyl]-4-ethoxy-3-ethyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine

HRID 68746

반응식

HRID 68746 반응식
[CH3:1][CH:2]1[NH:7][CH:6]([CH3:8])[CH2:5][N:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[N:20]=[C:19]4[N:21]([C:26]5[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=5)[N:22]=[C:23]([CH2:24][CH3:25])[C:18]4=[C:17]([O:32][CH3:33])[CH:16]=3)=[CH:11][CH:10]=2)[CH2:3]1.[C:34](OC(N1C(C)CNCC1C)=O)(C)(C)C.Cl>>[CH3:1][CH:2]1[NH:7][CH:6]([CH3:8])[CH2:5][N:4]([C:9]2[CH:10]=[CH:11][C:12]([C:15]3[N:20]=[C:19]4[N:21]([C:26]5[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=5)[N:22]=[C:23]([CH2:24][CH3:25])[C:18]4=[C:17]([O:32][CH2:33][CH3:34])[CH:16]=3)=[CH:13][CH:14]=2)[CH2:3]1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 222199261-Boc-2,6-dimethylpiperazineHCID 584835716-[4-(3,5-dimethyl-piperazin-1-yl)-phenyl]-3-ethyl-4-methoxy-1-phenyl-1H-pyrazolo[3,4-b]pyridine

생성물 1

HCID 584836406-[4-(3,5-Dimethyl-piperazin-1-yl)-phenyl]-4-ethoxy-3-ethyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine

실험 절차

The title compound was prepared according to the procedure as described in Example 98 reacting 6-(4-bromo-phenyl)-3-ethyl-4-ethoxy-1-phenyl-1H-pyrazolo[3,4-b]pyridine (according to Example 98) and 2,6-dimethyl-piperazine-1-carboxylic acid tert-butyl ester, followed by de-protection with HCl.

출처 및 근거

ORD 기록
ord-125ebe4381de463c9b3b3a141f905333
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822447B2

연결된 노트

불러오는 중…