Sodium Hydroxide → 4-(4-Methyloxazol-5-yl)benzoic acid

HRID 68761노트

반응식

HRID 68761 반응식
C[O:2][C:3](=[O:16])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:14][CH:13]=[N:12][C:11]=2[CH3:15])=[CH:6][CH:5]=1.[OH-].[Na+]>CO>[CH3:15][C:11]1[N:12]=[CH:13][O:14][C:10]=1[C:7]1[CH:8]=[CH:9][C:4]([C:3]([OH:16])=[O:2])=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 682895774-(4-Methyl-oxazol-5-yl)-benzoic acid methyl ester

생성물 1

HCID 682900554-(4-Methyloxazol-5-yl)benzoic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 4-(4-methyl-oxazol-5-yl)-benzoic acid methyl ester (1.50 g), 1 M aqueous NaOH solution (7.00 mL) and methanol (20 mL) is kept at room temperature overnight. The precipitate is filtered off, dissolved in water and neutralized with 4 M HCl. The precipitate is filtered off, dissolved in dichloromethane and a small amount of methanol, and the solution is dried over Na2SO4 and concentrated in vacuo. The residue is triturated with diethylether to afford the title compound. Mass spectrum (ESI+): m/z=204 [M+H]+.

후처리

  1. filtrationThe precipitate is filtered off
  2. dissolutiondissolved in water and neutralized with 4 M HCl
  3. filtrationThe precipitate is filtered off
  4. dissolutiondissolved in dichloromethane
  5. dry with materiala small amount of methanol, and the solution is dried over Na2SO4
  6. concentrationconcentrated in vacuo
  7. customThe residue is triturated with diethylether

출처 및 근거

ORD 기록
ord-5bd8e7b8bd6e406aaeec05900acc07b0
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822471B2

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