Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 68788생성일: 2026년 10월 26일
4-Hydroxypiperidine-1-carbonitrile → 1-(3-Isopropyl-1,2,4-oxadiazol-5-YL)piperidin-4-OL
https://huagongshe.com/reaction/68788
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Hydroxypiperidine-1-carbonitrile | HCID 21897825 | — |
| 반응물 | HCID 178449908 | HCID 178449908 | — |
| 촉매 | Zincchloride | HCID 3007855 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-(3-Isopropyl-1,2,4-oxadiazol-5-YL)piperidin-4-OL | HCID 21897744 | — |
반응 단계
4-Hydroxypiperidine-1-carbonitrile (3.0 g) and N-hydroxy-2-methylpropanimidamide (2.9 g) are dissolved in ethyl acetate (20 ml) and 1 M ZnCl2 in Et2O (29 ml) is added. A precipitate forms and the solvent is decanted off. Additional Et2O (20 ml) is added to wash the precipitate and again is decanted off. Ethanol (20 ml) is added followed by concentrated aqueous HCl (7.5 ml) and the mixture is heated to 100° C. for 3.5 h.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08822471B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-7965278f0abf44a5b7fbd8f75fc4af5e |
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| 출처 메모 | uspto-grants-2014_09 |
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