反应详情

温度

100 °C

4-Hydroxypiperidine-1-carbonitrile (3.0 g) and N-hydroxy-2-methylpropanimidamide (2.9 g) are dissolved in ethyl acetate (20 ml) and 1 M ZnCl2 in Et2O (29 ml) is added. A precipitate forms and the solvent is decanted off. Additional Et2O (20 ml) is added to wash the precipitate and again is decanted off. Ethanol (20 ml) is added followed by concentrated aqueous HCl (7.5 ml) and the mixture is heated to 100° C. for 3.5 h.

1. customA precipitate forms and the solvent is decanted off
2. additionAdditional Et2O (20 ml) is added
3. washto wash the precipitate
4. customagain is decanted off
5. additionEthanol (20 ml) is added