1-Bromo-3-chloropropane → HCID 66961254, 화합물

HRID 68999

반응식

HRID 68999 반응식
[C:1](=[O:4])([O-])[O-].[K+].[K+].[OH:7][C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][CH:17]=1)[N:14]=[C:13](OC)[CH:12]=[CH:11]2.[Cl:20][CH2:21][CH2:22][CH2:23]Br>C(#N)C.O>[Cl:20][CH2:21][CH2:22][CH2:23][O:7][C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][CH:17]=1)[N:14]([CH3:13])[C:1](=[O:4])[CH:12]=[CH:11]2

참가 물질

6

반응물 3

HCID 80061-Bromo-3-chloropropaneHCID 11430Potassium CarbonateHCID 450911926-Hydroxy-2-methoxyquinoline

생성물 1

HCID 66961254HCID 66961254, 화합물

시약·촉매·용매 2

HCID 962Water용매2회HCID 6342Acetonitrile용매

실험 절차

Potassium carbonate (0.829 g) was dissolved in acetonitrile (10 ml) and water (10 ml), and 6-hydroxy-2-methoxyquinoline (0.875 g) and 1-chloro-3-bromopropane (1.48 ml) was added thereto, and the mixture was stirred while heating under reflux for 4 hours. The reaction mixture was condensed under reduced pressure. Water was added to the residue, followed by extraction using ethyl acetate. The organic layer was dried with sodium sulfate, and was condensed under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=1:1). The purified product was condensed to dryness under reduced pressure to give the title compound (1.107 g) as a white powder.

후처리

  1. temperaturewhile heating
  2. temperatureunder reflux for 4 hours
  3. customcondensed under reduced pressure
  4. extractionfollowed by extraction
  5. dry with materialThe organic layer was dried with sodium sulfate
  6. customcondensed under reduced pressure
  7. customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=1:1)
  8. customcondensed to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-6af2b31558e94fa4a1dc4925a91fd34a
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822453B2

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