Sodium Sulfite → HCID 178515288, 화합물

HRID 69044

반응식

HRID 69044 반응식
[Br:1]N1C(=O)CCC1=O.[OH:9][C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]=[CH:12][CH:11]=1.C(=O)([O-])O.[Na+].S([O-])([O-])=O.[Na+].[Na+]>CN(C=O)C>[Br:1][C:11]1[CH:12]=[N:13][C:14]2[C:19]([C:10]=1[OH:9])=[CH:18][CH:17]=[CH:16][CH:15]=2

참가 물질

6

반응물 4

HCID 24437Sodium SulfiteHCID 67184N-bromobutanimideHCID 516892Sodium BicarbonateHCID 178516385quinolin-4-ol

생성물 1

HCID 178515288HCID 178515288, 화합물수율 71.3%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

N-Bromosuccinimide (1.3 g) was added to a DMF solution (15 ml) of 4-hydroxy quinoline (1.0 g) and the mixture was stirred at room temperature for 15 hours. A sodium hydrogencarbonate aqueous solution of 25% sodium sulfite was added to the mixture. The mixture was stirred and the precipitated insoluble matter was separated. The filtrate was dissolved in a mixture of ethyl acetate and methanol, and an insoluble matter was removed by filtration. The filtrate was condensed under reduced pressure, and the residue was washed with ethyl acetate and dried to give the title compound (1.1 g) as a white powder.

후처리

  1. stirringThe mixture was stirred
  2. customthe precipitated insoluble matter was separated
  3. dissolutionThe filtrate was dissolved in a mixture of ethyl acetate and methanol
  4. customan insoluble matter was removed by filtration
  5. customcondensed under reduced pressure
  6. washthe residue was washed with ethyl acetate
  7. customdried

출처 및 근거

ORD 기록
ord-216f17993b204565b8b69a733f2d9dec
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822453B2

연결된 노트

불러오는 중…