4-Nitro-3-(2-pyrrolidin-1-yl-ethylamino)-benzoic acid methyl ester → HCID 57917314, 화합물

HRID 69142노트

반응식

HRID 69142 반응식
[CH3:1][O:2][C:3](=[O:21])[C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-])=O)=[C:6]([NH:13][CH2:14][CH2:15][N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)[CH:5]=1>CO.C1COCC1.[Ni]>[CH3:1][O:2][C:3](=[O:21])[C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[C:6]([NH:13][CH2:14][CH2:15][N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)[CH:5]=1

참가 물질

4

반응물 1

HCID 579173564-Nitro-3-(2-pyrrolidin-1-yl-ethylamino)-benzoic acid methyl ester

생성물 1

HCID 57917314HCID 57917314, 화합물

시약·촉매·용매 2

HCID 935Nickel촉매HCID 21899815MeOH tetrahydrofuran용매

실험 절차

4-Nitro-3-(2-pyrrolidin-1-yl-ethylamino)-benzoic acid methyl ester (xiii) (1.30 g, 4.42 mmol) was shaken in MeOH/THF 1:1 (40 mL) in presence of Raney nickel under 1.1 bar H2 at rt for 40 min. The catalyst was filtered off and washed with MeOH. The filtrate was evaporated to give the title compound as an oil (tR 2.05 min (conditions 8), MH+=264).

후처리

  1. filtrationThe catalyst was filtered off
  2. washwashed with MeOH
  3. customThe filtrate was evaporated

출처 및 근거

ORD 기록
ord-f5692c16fcfe4d2895f31b62da87a115
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822468B2

반응 노트

불러오는 중…