Tetrahydrofuran → 4-{5-Chloro-2-[(2-hydroxy-1,1-dimethylethyl)amino]-1,3-thiazol-4-yl}benzonitrile

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[BH4-:21].[Cl:1][c:2]1[c:3](-[c:13]2[cH:14][cH:15][c:16]([C:17]#[N:18])[cH:19][cH:20]2)[n:4][c:5]([NH:7][C:8]([CH:9]=[O:10])([CH3:11])[CH3:12])[s:6]1.[Li+:22].[O:23]1[CH2:24][CH2:25][CH2:26][CH2:27]1>>[Cl:1][c:2]1[c:3](-[c:13]2[cH:14][cH:15][c:16]([C:17]#[N:18])[cH:19][cH:20]2)[n:4][c:5]([NH:7][C:8]([CH2:9][OH:10])([CH3:11])[CH3:12])[s:6]1