6-Phenylnicotinic acid → 6-phenylnicotinic acid N'-(4-methoxybutyryl)hydrazide

HRID 6926

반응식

HRID 6926 반응식
[C:1]1([C:7]2[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH3:17][O:18][CH2:19][CH2:20][CH2:21][C:22]([NH:24][NH2:25])=[O:23].Cl.C(N=C=NCCCN(C)C)C>N1C=CC=CC=1>[CH3:17][O:18][CH2:19][CH2:20][CH2:21][C:22]([NH:24][NH:25][C:11](=[O:13])[C:10]1[CH:14]=[CH:15][C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[N:8][CH:9]=1)=[O:23]

참가 물질

5

반응물 3

HCID 1201186-Phenylnicotinic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 865902274-Methoxybutyric acid hydrazide hydrochloride salt

생성물 1

HCID 695844476-phenylnicotinic acid N'-(4-methoxybutyryl)hydrazide수율 65.3%

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
60 °C

실험 절차

6-Phenylnicotinic acid (5.90 g) was dissolved in pyridine (150 ml), followed by addition of 4-methoxybutyric acid hydrazide hydrochloride salt (5.99 g) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride salt (8.51 g), and stirred at 60° C. for 10 hours. After the reaction solution was cooled to ambient temperature, the solvent was evaporated under reduced pressure. The resulting residue was washed with water, to afford 6-phenylnicotinic acid N′-(4-methoxybutyryl)hydrazide as pale yellow solid (6.06 g, 65%). The physico-chemical values are as follows.

후처리

  1. temperatureAfter the reaction solution was cooled to ambient temperature
  2. customthe solvent was evaporated under reduced pressure
  3. washThe resulting residue was washed with water

출처 및 근거

ORD 기록
ord-e17521f35c844b38b7cd816a96b56009
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084164B2

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