Hydrochloric Acid → 2-{2-[3-Fluoro-4-((R)-3-methylamino-pyrrolidin-1-yl)-phenyl]-1-oxo-1,2,3,4-tetrahydro-isoquinolin-6-yloxy}-N-methyl-acetamide

HRID 69430

반응식

C(O[C:6](=O)[N:7]([C@@H:9]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:29][CH2:28][C:27]4[C:22](=[CH:23][CH:24]=[C:25]([OH:30])[CH:26]=4)[C:21]3=[O:31])=[CH:16][C:15]=2[F:32])[CH2:10]1)C)(C)(C)C.Cl[CH2:35][C:36]([NH:38][CH3:39])=[O:37].Cl>>[F:32][C:15]1[CH:16]=[C:17]([N:20]2[CH2:29][CH2:28][C:27]3[C:22](=[CH:23][CH:24]=[C:25]([O:30][CH2:35][C:36]([NH:38][CH3:39])=[O:37])[CH:26]=3)[C:21]2=[O:31])[CH:18]=[CH:19][C:14]=1[N:11]1[CH2:12][CH2:13][C@@H:9]([NH:7][CH3:6])[CH2:10]1

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 667732-chloro-N-methylacetamide

HCID 68991872{(R)-1-[2-fluoro-4-(6-hydroxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-phenyl]-pyrrolidin-3-yl}-methyl-carbamic acid tert-butyl ester

생성물 1

HCID 579167482-{2-[3-Fluoro-4-((R)-3-methylamino-pyrrolidin-1-yl)-phenyl]-1-oxo-1,2,3,4-tetrahydro-isoquinolin-6-yloxy}-N-methyl-acetamide

실험 절차

According to Method K, {(R)-1-[2-fluoro-4-(6-hydroxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-phenyl]-pyrrolidin-3-yl}-methyl-carbamic acid tert-butyl ester was alkylated with 2-chloro-N-methyl-acetamide and the product was treated with hydrogen chloride (5 N in 2-propanol), releasing the amine. In this way the product was obtained with molecular weight 426.50 (C23H27FN4O3); MS (ESI): 427 (M+H+).

후처리

customIn this way the product was obtained with molecular weight 426.50 (C23H27FN4O3)

출처 및 근거

ORD 기록: ord-980def12b5e24a16b05691648be0d956
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08822495B2

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