N-Formylmorpholine → (S)-7-[4-(6-methoxy-1-oxo-1H-isoquinolin-2-yl)-phenyl]-2,7-diaza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester

HRID 69440

반응식

HRID 69440 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][C@:10]2([CH2:16][CH2:15][N:14]([C:17]3[CH:22]=[CH:21][C:20]([NH:23][C:24](=[O:34])[C:25]4[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][C:26]=4[CH3:33])=[CH:19][CH:18]=3)[CH2:13]2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH:35](N1CCOCC1)=O>>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][C@:10]2([CH2:16][CH2:15][N:14]([C:17]3[CH:18]=[CH:19][C:20]([N:23]4[CH:35]=[CH:33][C:26]5[C:25](=[CH:30][CH:29]=[C:28]([O:31][CH3:32])[CH:27]=5)[C:24]4=[O:34])=[CH:21][CH:22]=3)[CH2:13]2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 20417N-FormylmorpholineHCID 68990294(S)-7-[4-(4-methoxy-2-methyl-benzoylamino)-phenyl]-2,7-diaza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester

생성물 1

HCID 68991895(S)-7-[4-(6-methoxy-1-oxo-1H-isoquinolin-2-yl)-phenyl]-2,7-diaza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester

실험 절차

According to Method Q, (S)-7-[4-(4-methoxy-2-methyl-benzoylamino)-phenyl]-2,7-diaza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester was reacted with N-formylmorpholine. In this way the product was obtained with molecular weight 475.59 (C28H33N3O4); MS (ESI): 476 (M+H+).

후처리

  1. customIn this way the product was obtained with molecular weight 475.59 (C28H33N3O4)

출처 및 근거

ORD 기록
ord-25f4184ad4484b859f623f7b0c021127
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822495B2

연결된 노트

불러오는 중…