Water → 5-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-indan-1-one

HRID 69502

반응식

HRID 69502 반응식
[OH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[CH2:6][CH2:5]2.[O:12]1[CH2:16][CH2:15][CH2:14][C@@H:13]1[CH2:17]OS(C)(=O)=O.O>CN(C=O)C>[O:12]1[CH2:16][CH2:15][CH2:14][C@@H:13]1[CH2:17][O:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[CH2:6][CH2:5]2

참가 물질

5

반응물 3

HCID 962WaterHCID 2331475-Hydroxy-1-indanoneHCID 18649742HCID 18649742, 화합물

생성물 1

HCID 689893065-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-indan-1-one

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 5-hydroxyindanone (80 mg) and methanesulfonic acid (R)-1-(tetrahydrofuran-2-yl)methyl ester (107 mg) in DMF (1 mL) was stirred at 70° C. for 16 h. After adding water it was extracted with ether, dried over magnesium sulfate and concentrated. The residue was chromatographed on silica gel. In this way the product was obtained with molecular weight 232.28 (C14H16O3); MS (ESI): 233 (M+H+).

후처리

  1. extractionwas extracted with ether
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated
  4. customThe residue was chromatographed on silica gel
  5. customIn this way the product was obtained with molecular weight 232.28 (C14H16O3)

출처 및 근거

ORD 기록
ord-7f3e6357e7c0499d9f9a3072dd89921e
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822495B2

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