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Water → 2-Bromo-6-[4-((R)-3-dimethylamino-pyrrolidin-1-yl)-phenyl]-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one

HRID 69503
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인쇄 미리보기

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HRID 69503 반응식
[H-].[Na+].[CH3:3][N:4]([CH3:28])[C@@H:5]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:17]([C:19]3[S:20][C:21]([Br:27])=[CH:22][C:23]=3[CH2:24][CH2:25]Cl)=[O:18])=[CH:12][CH:11]=2)[CH2:6]1.O.C(OCC)(=O)C>C1COCC1>[Br:27][C:21]1[S:20][C:19]2[C:17](=[O:18])[N:16]([C:13]3[CH:14]=[CH:15][C:10]([N:7]4[CH2:8][CH2:9][C@@H:5]([N:4]([CH3:28])[CH3:3])[CH2:6]4)=[CH:11][CH:12]=3)[CH2:25][CH2:24][C:23]=2[CH:22]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 24758Sodium hydrideHCID 866351065-Bromo-3-(2-chloro-ethyl)-thiophene-2-carboxylic acid [4-((R)-3-dimethylamino-pyrrolidin-1-yl)-phenyl]-amide

생성물 1

HCID 689912052-Bromo-6-[4-((R)-3-dimethylamino-pyrrolidin-1-yl)-phenyl]-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one

시약·촉매·용매 1

HCID 8028
Tetrahydrofuran
용매

실험 절차

NaH (60% in oil; 175.4 mg) was added in small portions to a solution of 5-Bromo-3-(2-chloro-ethyl)-thiophene-2-carboxylic acid [4-((R)-3-dimethylamino-pyrrolidin-1-yl)-phenyl]-amide (612.2 mg) in THF (3.1 mL) at 0° C. The mixture was warmed to room temperature and stirred over night. Water and ethyl acetate was added to the mixture. The aqueous phase was extracted with ethyl acetate three times. The combined organic phases were dried over sodium sulfate and the solvent was removed in vacuum. In this way the product was obtained with molecular weight 420.37 (C19H22BrN3OS); MS (ESI): 420, 422 (M+H+).

후처리

  1. extractionThe aqueous phase was extracted with ethyl acetate three times
  2. dry with materialThe combined organic phases were dried over sodium sulfate
  3. customthe solvent was removed in vacuum
  4. customIn this way the product was obtained with molecular weight 420.37 (C19H22BrN3OS)

출처 및 근거

ORD 기록
ord-50728025cb1a459aadf29e0453dcba3f
출처 데이터셋
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08822495B2

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