Lithium Hydroxide → 2-Chloro-4-methylbenzoic acid
반응식
[Cl:1][C:2]1[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[OH-].[Li+]>O1CCCC1.O>[Cl:1][C:2]1[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]참가 물질
5
반응 조건
- 온도
- 50 °C
실험 절차
To methyl 2-chloro-4-methylbenzoate (1.00 g, 5.42 mmol) in tetrahydrofuran (10 mL) methyl alcohol (5 mL) and water (2.5 mL) is added 2N lithium hydroxide (8.12 mL, 16.2 mmol). The reaction mixture is heated at 50° C. for 2.5 hr, cooled to room temperature, and then quenched with 5N hydrochloric acid (3.24 mL). The mixture is concentrated to remove the tetrahydrofuran and methyl alcohol. A white precipitate is formed and is filtered. After drying, 0.922 g (100%) of 2-chloro-4-methylbenzoic acid is isolated. ES(−)MS m/z 169, (M−H)− consistent with 1 Cl.
후처리
- temperaturecooled to room temperature
- customquenched with 5N hydrochloric acid (3.24 mL)
- concentrationThe mixture is concentrated
- customto remove the tetrahydrofuran and methyl alcohol
- customA white precipitate is formed
- filtrationis filtered
- customAfter drying
출처 및 근거
- ORD 기록
- ord-cea61636641643349db50d2479857ff0
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07084170B2
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