Piperazine → N-methyl-4-(piperazin-1-yl)benzene-1-sulfonamide
반응식
F[C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH3:12])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>O>[CH3:12][NH:11][S:8]([C:5]1[CH:6]=[CH:7][C:2]([N:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[CH:3][CH:4]=1)(=[O:10])=[O:9]참가 물질
4
반응 조건
- 온도
- 120 °C
실험 절차
4-fluoro-N-methylbenzenesulfonamide (189 mg, 0.999 mmol) and piperazine (430 mg, 4.99 mmol) were combined and the reaction mixture was stirred at 120° C. for 2 h. It was diluted with water (5 mL) and stirred until a fine suspension resulted. The precipitate was filtered, washed with water (5×3 mL) and dried in vacuum to afford N-methyl-4-(piperazin-1-yl)benzenesulfonamide (222 mg, 0.869 mmol, 87% yield) as a white solid. ESI-MS: m/z 256 (M+H)+.
후처리
- stirringstirred until a fine suspension
- customresulted
- filtrationThe precipitate was filtered
- washwashed with water (5×3 mL)
- customdried in vacuum
출처 및 근거
- ORD 기록
- ord-8ffc550874ab49deaf3f150f3c66c61d
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08822470B2
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