1,3-Difluoro-2-nitrobenzene → tert-Butyl 1-(3-fluoro-2-nitrophenyl)piperidine-4-ylcarbamate

HRID 69838

반응식

HRID 69838 반응식
F[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[N+:9]([O-:11])=[O:10].[C:12]([NH:19][CH:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13]>CCO>[F:8][C:4]1[C:3]([N+:9]([O-:11])=[O:10])=[C:2]([N:23]2[CH2:22][CH2:21][CH:20]([NH:19][C:12](=[O:13])[O:14][C:15]([CH3:17])([CH3:16])[CH3:18])[CH2:25][CH2:24]2)[CH:7]=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 879221,3-Difluoro-2-nitrobenzeneHCID 7238334-(N-Boc-amino)piperidine

생성물 1

HCID 53255566tert-Butyl 1-(3-fluoro-2-nitrophenyl)piperidine-4-ylcarbamate수율 93%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Method 1 was followed using 1 eq each of 2,6-difluoronitrobenzene, 4-(N-Boc-amino) piperidine, and TEA in EtOH yielding tert-butyl 1-(3-fluoro-2-nitrophenyl)piperidin-4-ylcarbamate (93%). LCMS (m/z): 340.1 (MH+); LC Rt=3.30 min.

출처 및 근거

ORD 기록
ord-59927f3e78434f798cfb8d58841466f5
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822497B2

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