Diisopropylethylamine → 6-amino-5-(3-fluoropiperidin-1-yl)pyrimidin-2(1H)-one

HRID 69876노트

반응식

HRID 69876 반응식
Br[C:2]1[C:3]([NH2:9])=[N:4][C:5](=[O:8])[NH:6][CH:7]=1.[F:10][CH:11]1[CH2:16][CH2:15][CH2:14][NH:13][CH2:12]1.C(N(C(C)C)CC)(C)C>>[NH2:9][C:3]1[NH:4][C:5](=[O:8])[N:6]=[CH:7][C:2]=1[N:13]1[CH2:14][CH2:15][CH2:16][CH:11]([F:10])[CH2:12]1

참가 물질

4

반응물 3

HCID 81531DiisopropylethylamineHCID 27591573-FluoropiperidineHCID 178509018HCID 178509018, 화합물

생성물 1

HCID 690435896-amino-5-(3-fluoropiperidin-1-yl)pyrimidin-2(1H)-one

실험 절차

Method 8 was followed using 1 eq. of 5-bromocytosine, 1.25 eq. of 3-fluoropiperidine and 2.5 eq. of diisopropylethylamine at 120° C. for 2 days yielding 6-amino-5-(3-fluoropiperidin-1-yl)pyrimidin-2(1H)-one as an orange crunchy solid (24%). LCMS (m/z): 213.0 (MH+); LC Rt=1.07 min.

후처리

  1. customat 120° C.
  2. customfor 2 days

출처 및 근거

ORD 기록
ord-ea72114d63de436a879afc0f32312ef3
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822497B2

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