3-Amino-6-bromopicolinic acid → trans-(+/-)-Tert-butyl 1-(3-(3-amino-6-bromopicolinamido)pyridin-4-yl)-4-fluoropiperidin-3-ylcarbamate

HRID 69929

반응식

HRID 69929 반응식
[NH2:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[N:8]1[CH2:13][CH2:12][C@@H:11]([F:14])[C@H:10]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[CH2:9]1.[NH2:23][C:24]1[C:25]([C:31](O)=[O:32])=[N:26][C:27]([Br:30])=[CH:28][CH:29]=1>>[NH2:23][C:24]1[C:25]([C:31]([NH:1][C:2]2[CH:3]=[N:4][CH:5]=[CH:6][C:7]=2[N:8]2[CH2:13][CH2:12][C@@H:11]([F:14])[C@H:10]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:19])([CH3:21])[CH3:20])[CH2:9]2)=[O:32])=[N:26][C:27]([Br:30])=[CH:28][CH:29]=1

참가 물질

3

반응물 2

HCID 454804523-Amino-6-bromopicolinic acidHCID 58386807HCID 58386807, 화합물

생성물 1

HCID 88862444trans-(+/-)-Tert-butyl 1-(3-(3-amino-6-bromopicolinamido)pyridin-4-yl)-4-fluoropiperidin-3-ylcarbamate

실험 절차

Following Method 11 of Example 305, trans-(+/−)-tert-butyl 1-(3-aminopyridin-4-yl)-4-fluoropiperidin-3-ylcarbamate and 3-amino-6-bromopicolinic acid were reacted yielding after purification (+/−)-tert-butyl 1-(3-(3-amino-6-bromopicolinamido)pyridin-4-yl)-4-fluoropiperidin-3-ylcarbamate, (20%). LCMS (m/z): 510.9 (MH+).

후처리

  1. customwere reacted
  2. customyielding
  3. customafter purification (+/−)-tert-butyl 1-(3-(3-amino-6-bromopicolinamido)pyridin-4-yl)-4-fluoropiperidin-3-ylcarbamate, (20%)

출처 및 근거

ORD 기록
ord-5b3278def8a849c395f40af2ffc1049a
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822497B2

연결된 노트

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