cis-2-Aminocycloheptanecarboxylic acid methyl ester → HCID 69655884, 화합물

HRID 7025

반응식

HRID 7025 반응식
C[O:2][C:3]([C@@H:5]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][C@@H:6]1[NH2:12])=O.[NH4+:13].[OH-].O>>[NH2:12][C@H:6]1[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C@H:5]1[C:3]([NH2:13])=[O:2]

참가 물질

3

반응물 2

HCID 1512672cis-2-Aminocycloheptanecarboxylic acid methyl esterHCID 86589665Water ammonium hydroxide

생성물 1

HCID 69655884HCID 69655884, 화합물

실험 절차

cis-2-Aminocycloheptanecarboxylic acid methyl ester (1.65 g, 9.64 mmol) was treated with 20 mL of NH4OH/H2O and stirred at room temperature for 24 h. The solution was concentrated in vacuo and azeotroped once with toluene. The reaction afforded 2.20 g of cis-2-aminocycloheptanecarboxylic acid amide as a white solid: 1H NMR (DMSO-d6) δ 7.81 (m, 3 H), 7.20 (s, 1 H), 2.76 (m, 1 H), 1.68–1.40 (m, 11 H); MS m/e 157.28 (M+H)+.

후처리

  1. concentrationThe solution was concentrated in vacuo
  2. customazeotroped once with toluene

출처 및 근거

ORD 기록
ord-02ef1dfe6f1a403686e87c22720d628b
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084178B2

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