D-Psicose → Methyl 2-amino-4-(methylthio)benzoate

HRID 703046

반응식

HRID 703046 반응식
[CH3:1][S:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[C:5]([N+:13]([O-])=O)[CH:4]=1.OCC1(OC[C@@H](O)[C@@H](O)[C@H]1O)O.[H][H]>C(OC)(=O)C.[Pt]=S>[NH2:13][C:5]1[CH:4]=[C:3]([S:2][CH3:1])[CH:12]=[CH:11][C:6]=1[C:7]([O:9][CH3:10])=[O:8]

참가 물질

6

반응물 3

HCID 441036D-PsicoseHCID 139880444-Methylsulfanyl-2-nitro-benzoic acid methyl esterHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 13988045Methyl 2-amino-4-(methylthio)benzoate

시약·촉매·용매 2

HCID 82861Platinum sulfide (PtS)촉매HCID 6584Methyl Acetate용매

실험 절차

A mixture of methyl 4-(methylthio)-2-nitrobenzoate (11.3 g. 49.7 mmol) and 5% platinum sulfide on carbon catalyst (0.7 g) in methyl acetate (40 mL) was hydrogenated at 750 Psi and 75° C. until hydrogen uptake ceased. The mixture was filtered through Celite®, and the filtrate solvent was rotary evaporated, leaving methyl 2-amino-4-(methylthio)benzoate as a slightly tan crystalline solid (8.7 g) melting at 57°-59° C.

후처리

  1. filtrationThe mixture was filtered through Celite®

출처 및 근거

ORD 기록
ord-d2456382c81b41cba50b4677bd80b183
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04981509

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