Sodium Hydroxide → 3,5-Dimethyl-2-hydroxymethyl-4-methoxy-pyridine

HRID 703166노트

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HRID 703166 반응식
C([O:4][CH2:5][C:6]1[C:11]([CH3:12])=[C:10]([O:13][CH3:14])[C:9]([CH3:15])=[CH:8][N:7]=1)(=O)C.[OH-].[Na+]>C(O)C>[CH3:14][O:13][C:10]1[C:9]([CH3:15])=[CH:8][N:7]=[C:6]([CH2:5][OH:4])[C:11]=1[CH3:12]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 50672892-(Acetoxymethyl)-4-methoxy-3,5-dimethylpyridine

생성물 1

HCID 7378233,5-Dimethyl-2-hydroxymethyl-4-methoxy-pyridine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

94.9 g of (4-methoxy-3,5-dimethyl-2-pyridyl)methyl acetate were dissolved in 570 ml of ethanol. 285 ml of 3N sodium hydroxide solution were then added dropwise thereto at 0° and the mixture was stirred at room temperature for 3 hours. The ethanol was subsequently removed in vacuo, whereupon the residual aqueous solution was extracted three times with 300 ml of methylene chloride. The organic extracts were dried over sodium sulfate and evaporated in vacuo The residue was crystallized from petroleum ether and there was obtained 4-methoxy-3,5-dimethyl-2-pyridylmethanol of melting point 49-51° .

후처리

  1. customThe ethanol was subsequently removed in vacuo, whereupon the residual aqueous solution
  2. extractionwas extracted three times with 300 ml of methylene chloride
  3. dry with materialThe organic extracts were dried over sodium sulfate
  4. customevaporated in vacuo The residue
  5. customwas crystallized from petroleum ether

출처 및 근거

ORD 기록
ord-1f1952b0c1cf476b9e6a413c3bc1ce3d
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04981861

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