Sodium Hydroxide → (4-Methoxy-5-methylpyridin-2-yl)methanol
반응식
C([O:4][CH2:5][C:6]1[CH:11]=[C:10]([O:12][CH3:13])[C:9]([CH3:14])=[CH:8][N:7]=1)(=O)C.[OH-].[Na+]>C(O)C>[CH3:13][O:12][C:10]1[C:9]([CH3:14])=[CH:8][N:7]=[C:6]([CH2:5][OH:4])[CH:11]=1참가 물질
4
실험 절차
47.8 g of (4-methoxy-5-methyl-2-pyridyl)methyl acetate were dissolved in 330 ml of ethanol. 165 ml of 3N sodium hyroxide solution were then added dropwise thereto at 0° and the mixture was stirred at room temperature for a further 3 hours. The ethanol was subsequently removed in vacuo, whereupon the residual aqueous solution was extracted three times with 250 ml of methylene chloride. The organic extracts were dried over sodium sulfate and evaporated in vacuo. The residue crystallizes from petroleum ether and there was obtained 4-methoxy-5-methyl-2-pyridylmethanol of melting point 101-103° .
후처리
- customThe ethanol was subsequently removed in vacuo, whereupon the residual aqueous solution
- extractionwas extracted three times with 250 ml of methylene chloride
- dry with materialThe organic extracts were dried over sodium sulfate
- customevaporated in vacuo
- customThe residue crystallizes from petroleum ether
출처 및 근거
- ORD 기록
- ord-a3a2589e6e8c4264bd69b0e31d4b5ac7
- 출처 데이터셋
- uspto-grants-1991_01
- 특허 번호
- US04981861
반응 노트
불러오는 중…