Hydrochloric Acid → HCID 86744465, 화합물

HRID 703280

반응식

HRID 703280 반응식
C([NH:9][CH2:10][C@@H:11]([C@H:16]([OH:18])[CH3:17])[C:12]([O:14]C)=[O:13])(=O)C1C=CC=CC=1.[ClH:19]>>[ClH:19].[NH2:9][CH2:10][C@@H:11]([C@H:16]([OH:18])[CH3:17])[C:12]([OH:14])=[O:13]

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 10060699(2S,3R)-methyl-2-benzamidomethyl-3-hydroxybutyrate

생성물 1

HCID 86744465HCID 86744465, 화합물수율 93%

실험 절차

To 10.65 g (42.43 mmole) of methyl (2S, 3R)-2-(N-benzoylamino)methyl-3-hydroxybutanoate was added 70 ml of a 10% hydrochloric acid aqueous solution at room temperature to form a solution. The solution was heated at reflux for 4.5 hours and then allowed to cool to room temperature. The precipitated benzoic acid was separated by filtration, and the filtrate was washed twice with 100 ml portions of toluene. The aqueous layer was concentrated under reduced pressure to obtain 6.67 g (yield: 93%) of (2S, 3R)-2-aminomethyl-3-hydroxybutanoic acid hydrochloride.

후처리

  1. customto form a solution
  2. temperatureThe solution was heated
  3. temperatureat reflux for 4.5 hours
  4. customThe precipitated benzoic acid was separated by filtration
  5. washthe filtrate was washed twice with 100 ml portions of toluene
  6. concentrationThe aqueous layer was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-b82bab42b2c1419abdb6c1462a26f5ac
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04981992

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