Dichloromethane → 3-(2,2,3,3,3-Pentafluoropropoxy)methyl-4-methyl-1-nitrobenzene

HRID 703344

반응식

HRID 703344 반응식
[CH3:1][C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[CH2:4]Cl.[F:13][C:14]([F:21])([C:17]([F:20])([F:19])[F:18])[CH2:15][OH:16].[OH-].[K+].ClCCl>CN(C)C=O>[F:13][C:14]([F:21])([C:17]([F:20])([F:19])[F:18])[CH2:15][O:16][CH2:4][C:3]1[CH:6]=[C:7]([N+:10]([O-:12])=[O:11])[CH:8]=[CH:9][C:2]=1[CH3:1]

참가 물질

6

반응물 4

HCID 6344DichloromethaneHCID 98722,2,3,3,3-PentafluoropropanolHCID 14797Potassium HydroxideHCID 1879522-(Chloromethyl)-1-methyl-4-nitrobenzene

생성물 1

HCID 150701683-(2,2,3,3,3-Pentafluoropropoxy)methyl-4-methyl-1-nitrobenzene

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

In 16.5 ml of dimethylformamide, 5.00 g (0.027 mol) of 2-methyl-5-nitrobenzyl chloride and 21.3 g (0.135 mol) of 2,2,3,3,3-pentafluoropropanol were dissolved. The solution was then added with 2.29 g (0.041 mol) of KOH pellets and stirred overnight. Dichloromethane was added and the precipitated salts were filtered out. The filtrate was acidified with dilute hydrochloric acid and then the solvents were distilled off.

후처리

  1. filtrationthe precipitated salts were filtered out
  2. distillationthe solvents were distilled off

출처 및 근거

ORD 기록
ord-fe6198eb9b0a45a8ba52b72219df5ea0
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04983209

연결된 노트

불러오는 중…