Hydrochloric Acid → 6-Chloro-N-(1H-indol-1-yl)-4-pyrimidinamine
반응식
C(O)(C)C.Cl[C:6]1[CH:11]=[C:10]([Cl:12])[N:9]=[CH:8][N:7]=1.Cl.[N:14]1([NH2:23])[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15]1>O>[Cl:12][C:10]1[N:9]=[CH:8][N:7]=[C:6]([NH:23][N:14]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:16]=[CH:15]2)[CH:11]=1참가 물질
6
반응 조건
- 온도
- 90 °C
실험 절차
To 250 ml isopropanol, was added 4,6-dichloropyrimidine (12 g), 1 ml ethereal -HCl, and 1H-indol-1-amine (15 g). After stirring at 90° C. for seven hours, the mixture was poured into 300 ml iced water, stirred for five minutes, then extracted three times with 200 ml of ethyl acetate. The organic layer was washed with water, then dried (saturated NaCl, anhydrous MgSO4).
후처리
- stirringstirred for five minutes
- extractionextracted three times with 200 ml of ethyl acetate
- washThe organic layer was washed with water
- dry with materialdried (saturated NaCl, anhydrous MgSO4)
출처 및 근거
- ORD 기록
- ord-27f244116b0d493693e72035fba7ed30
- 출처 데이터셋
- uspto-grants-1991_01
- 특허 번호
- US04983608
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