2,4-Difluorobenzenesulfonyl Chloride → 3-[(4-chloro-2-{[(2,4-difluorophenyl)sulfonyl]amino}phenyl)thio]-N,N-dimethylpropanamide

HRID 70364

반응식

HRID 70364 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[S:9][CH2:10][CH2:11][C:12]([N:14]([CH3:16])[CH3:15])=[O:13].[F:17][C:18]1[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:19]=1[S:25](Cl)(=[O:27])=[O:26]>N1C=CC=CC=1>[Cl:8][C:6]1[CH:5]=[CH:4][C:3]([S:9][CH2:10][CH2:11][C:12]([N:14]([CH3:15])[CH3:16])=[O:13])=[C:2]([NH:1][S:25]([C:19]2[CH:20]=[CH:21][C:22]([F:24])=[CH:23][C:18]=2[F:17])(=[O:27])=[O:26])[CH:7]=1

참가 물질

4

반응물 2

HCID 27342732,4-Difluorobenzenesulfonyl ChlorideHCID 609618703-((2-amino-4-chlorophenyl)thio)-N,N-dimethylpropanamide

생성물 1

HCID 679719053-[(4-chloro-2-{[(2,4-difluorophenyl)sulfonyl]amino}phenyl)thio]-N,N-dimethylpropanamide수율 72%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Following General Procedure B, the title compound (364 mg, 72%) was prepared from 3-((2-amino-4-chlorophenyl)thio)-N,N-dimethylpropanamide (300 mg, 1.167 mmol) and 2,4-difluorobenzene-1-sulfonyl chloride (248 mg, 1.167 mmol) in pyridine (5 ml).

출처 및 근거

ORD 기록
ord-30123de4357b44b796764f38e4f8299a
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822530B2

연결된 노트

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