Water → 2-Chloro-3-(trifluoromethyl)benzaldehyde

HRID 703659

반응식

HRID 703659 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([F:11])([F:10])[F:9].C([Li])CCC.CN(C)[CH:19]=[O:20].O>O1CCCC1.CCCCCC>[Cl:1][C:2]1[C:3]([C:8]([F:9])([F:10])[F:11])=[CH:4][CH:5]=[CH:6][C:7]=1[CH:19]=[O:20]

참가 물질

7

반응물 4

HCID 962WaterHCID 6228DimethylformamideHCID 69211-Chloro-2-(trifluoromethyl)benzeneHCID 178418339Butyllithium

생성물 1

HCID 27366722-Chloro-3-(trifluoromethyl)benzaldehyde

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매2회HCID 8058Hexane용매

실험 절차

A solution of 0.6 mole of 2-chlorotrifluoromethylbenzene in 1 l of tetrahydrofuran is cooled to -65° C. and 0.58 mole of butyllithium dissolved in hexane is added. The mixture is maintained at the same temperature for 2 hours and a mixture containing 44 ml of dimethylformamide and 200 ml of tetrahydrofuran is then added dropwise. The reaction medium is allowed to return to ambient temperature, 600 ml of water are added, extraction is then carried out with ethyl ether followed by evaporation to dryness. The product is distilled to purify.

후처리

  1. additionis added
  2. temperatureThe mixture is maintained at the same temperature for 2 hours
  3. additionis then added dropwise
  4. customto return to ambient temperature
  5. extractionextraction
  6. customfollowed by evaporation to dryness
  7. distillationThe product is distilled
  8. customto purify

출처 및 근거

ORD 기록
ord-670b13ab1d164970a6e199b584e6fcfe
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04983740

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