Sulfuric Acid → Ethyl 3-[1-(4-chlorophenyl)-2,2-dimethylpropylidene]carbazate

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[C:1]([C:5]([C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1)=O)([CH3:4])([CH3:3])[CH3:2].[C:14]([O:18][CH2:19][CH3:20])(=[O:17])[NH:15][NH2:16].S(=O)(=O)(O)O>C(O)C>[Cl:13][C:10]1[CH:11]=[CH:12][C:7]([C:5](=[N:16][NH:15][C:14]([O:18][CH2:19][CH3:20])=[O:17])[C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:8][CH:9]=1

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실험 절차

A solution of 4.92 g (0.025 mol) 4-chlorphenyl tert.-butyl ketone and 8.05 g (0.075 mol) ethyl carbazate in 125 ml absolute ethanol was treated with ca. 0.3 g concentrated sulphuric acid and heated at reflux for 3 hours. The solution was then concentrated in vacuo and the residue added to water. It was then extracted with ethyl acetate, the organic phase dried with magnesium sulphate, concentrated and the residue recrystallised from diisopropyl ether.