Potassium Carbonate → 5-Fluoro-2-((3-nitrobenzyl)thio)aniline

HRID 70378

반응식

HRID 70378 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[SH:9].Br[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[F:8][C:6]1[CH:5]=[CH:4][C:3]([S:9][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=2)=[C:2]([CH:7]=1)[NH2:1]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 77568Benzene, 1-(bromomethyl)-3-nitro-HCID 111054802-Amino-4-fluorobenzene-1-thiol

생성물 1

HCID 433044165-Fluoro-2-((3-nitrobenzyl)thio)aniline수율 97%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Following General Procedure A, the title compound (460 mg, 97%) was prepared from 2-amino-4-fluorobenzenethiol (562 g, 3.93 mmol), 1-(bromomethyl)-3-nitrobenzene (566 mg, 2.62 mmol), K2CO3 (1.8 g, 13.10 mmol) in DMF (10 ml).

출처 및 근거

ORD 기록
ord-697136108b5845e3b32265b19abeb3d1
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822530B2

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