Methyl bromoacetate → N-(2,6-Difluorophenyl)glycine methyl ester

HRID 703803

반응식

HRID 703803 반응식
[F:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([F:9])[C:3]=1[NH2:4].C(=O)(O)[O-].[Na+].Br[CH2:16][C:17]([O:19][CH3:20])=[O:18]>ClCC(OC)=O>[CH3:20][O:19][C:17](=[O:18])[CH2:16][NH:4][C:3]1[C:2]([F:1])=[CH:8][CH:7]=[CH:6][C:5]=1[F:9]

참가 물질

5

반응물 3

HCID 60984Methyl bromoacetateHCID 796472,6-DifluoroanilineHCID 516892Sodium Bicarbonate2회

생성물 1

HCID 20074950N-(2,6-Difluorophenyl)glycine methyl ester

시약·촉매·용매 1

HCID 7295Methyl chloroacetate용매

실험 절차

A suspension of 2,6-difluoroaniline (15.0 g) and sodium bicarbonate (19.5 g) in methyl chloroacetate (15.2 ml) was stirred at 90°-100° under nitrogen for 16 h. Methyl bromoacetate (11.0 ml) and sodium bicarbonate (9.75 g) were added, and the suspension was stirred at 90°-100° for a further 5 h. Work up according to the method of Intermediate 11 gave an oil (14.7 g) which was purified by FCC eluting with system A (1:8) to give the title compound (8.27 g) as an oil, t.l.c. (System A, 1:8) Rf 0.3.

후처리

  1. stirringthe suspension was stirred at 90°-100° for a further 5 h

출처 및 근거

ORD 기록
ord-22cb8750074b4234890d40afae535fcc
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04985427

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