Ammonia → 7-Amino-4,4-dimethyl-3,4-dihydroquinolin-2(1H)-one

HRID 703925노트

반응식

HRID 703925 반응식
C([NH:4][C:5]1[CH:14]=[C:13]2[C:8]([C:9]([CH3:17])([CH3:16])[CH2:10][C:11](=[O:15])[NH:12]2)=[CH:7][CH:6]=1)(=O)C.Cl.N>C(O)C>[NH2:4][C:5]1[CH:14]=[C:13]2[C:8]([C:9]([CH3:17])([CH3:16])[CH2:10][C:11](=[O:15])[NH:12]2)=[CH:7][CH:6]=1

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 14476477N-(4,4-dimethyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)acetamide

생성물 1

HCID 144764787-Amino-4,4-dimethyl-3,4-dihydroquinolin-2(1H)-one

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A suspension of 23.2 g. (0.1 mole) 7-acetamido-1,2,3,4-tetrahydro-4,4-dimethylquinolin-2-one, 200 ml. ethanol and 20 ml. concentrated hydrochloric acid is boiled under reflux until dissolving is complete. The pH value is then adjusted with ammonia to 8, the reaction mixture is extracted three times with dichloromethane and the organic phase is dried over anhydrous sodium sulphate and freed from solvent. Yield 13.1 g. (69% of theory); m.p. 161°-163° C.

후처리

  1. additionA suspension of 23.2 g
  2. temperatureunder reflux
  3. dissolutionuntil dissolving
  4. extractionthe reaction mixture is extracted three times with dichloromethane
  5. dry with materialthe organic phase is dried over anhydrous sodium sulphate

출처 및 근거

ORD 기록
ord-6a0695c6cac449ae9e80780588ce1b26
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04985448

반응 노트

불러오는 중…