N-(3-Aminopropyl)morpholine → N-[3-(4-Morpholinyl)propyl]-4-methylpyridazino[4,5-b]indolizin-1-amine

HRID 704076

반응식

HRID 704076 반응식
Cl[C:2]1[C:7]2[CH:8]=[C:9]3[N:14]([C:6]=2[C:5]([CH3:15])=[N:4][N:3]=1)[CH:13]=[CH:12][CH:11]=[CH:10]3.[NH2:16][CH2:17][CH2:18][CH2:19][N:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>>[N:20]1([CH2:19][CH2:18][CH2:17][NH:16][C:2]2[N:3]=[N:4][C:5]([CH3:15])=[C:6]3[N:14]4[C:9]([CH:10]=[CH:11][CH:12]=[CH:13]4)=[CH:8][C:7]=23)[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1

참가 물질

3

반응물 2

HCID 61055N-(3-Aminopropyl)morpholineHCID 157133121-Chloro-4-methylpyridazino[4,5-b]indolizine

생성물 1

HCID 15713316N-[3-(4-Morpholinyl)propyl]-4-methylpyridazino[4,5-b]indolizin-1-amine

실험 절차

Following the procedure of Example 1, reaction of one equivalent of 1-chloro-4-methylpyridazino[4,5-b]indolizine and 10 equivalents of 4-(3-aminopropyl)morpholine gave the title compound as the free base which was converted to the dihydrochloride salt, mp. 295°-296° C. (after recrystallization from ethanol).

출처 및 근거

ORD 기록
ord-a6000ef64477480795ef1f47757fc758
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04985560

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