Acetophenone, 2',4'-dichloro-5'-fluoro- → 2,4-Dichloro-5-fluorobenzoic acid

HRID 704110

반응식

C[C:2]([C:4]1[C:9]([Cl:10])=[CH:8][C:7]([Cl:11])=[C:6]([F:12])[CH:5]=1)=[O:3].[PH2]([O-])=[O:14].[Na+]>>[Cl:10][C:9]1[CH:8]=[C:7]([Cl:11])[C:6]([F:12])=[CH:5][C:4]=1[C:2]([OH:3])=[O:14]

참가 물질

반응물 2

HCID 727250Acetophenone, 2',4'-dichloro-5'-fluoro-

HCID 178527019HCID 178527019, 화합물

생성물 1

HCID 6881382,4-Dichloro-5-fluorobenzoic acid

실험 절차

Namely, 2,4-dichloro-5-fluoroacetophenone is subjected to a haloform reaction in a 12% sodium hypophosphite aqueous solution to obtain 2,4-dichloro-5-fluorobenzoic acid. Then, this benzoic acid is reacted with an alcohol or with a phenol in the presence of an acid catalyst to obtain the above-mentioned fluorine-containing benzoate.

출처 및 근거

ORD 기록: ord-aecb18ae08a242f6b4dacf28a42ba04f
출처 데이터셋: uspto-grants-1991_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04985588

연결된 노트

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