Acetone → 10-[1-(1-Pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxylic acid hydrochloride

HRID 704238

반응식

HRID 704238 반응식
[ClH:1].[N:2]1([CH2:7][CH:8]([N:10]2[C:23]3[CH:22]=C(C#N)[CH:20]=[CH:19][C:18]=3[S:17][C:16]3[C:11]2=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH3:9])[CH2:6][CH2:5][CH2:4][CH2:3]1.[OH-:26].[K+].Cl.C[C:30]([CH3:32])=[O:31]>C(OCC)C>[ClH:1].[N:2]1([CH2:7][CH:8]([N:10]2[C:23]3[CH:22]=[C:32]([C:30]([OH:26])=[O:31])[CH:20]=[CH:19][C:18]=3[S:17][C:16]3[C:11]2=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH3:9])[CH2:6][CH2:5][CH2:4][CH2:3]1

참가 물질

6

반응물 4

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 1902054310-[1-(1-Pyrrolidinyl)-2-propyl]-2-phenothiazinecarbonitrile hydrochloride

생성물 1

HCID 1453664010-[1-(1-Pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxylic acid hydrochloride

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

10-[(2RS)-1-(1-Pyrrolidinyl)-2-propyl]-2-phenothiazinecarbonitrile hydrochloride (3.72 g) is added to a solution of potassium hydroxide (1.7 g) in glycol (20 cc), and the mixture is stirred for 5 hours under reflux. After cooling, the yellow solution obtained is traeted with a 3N ethereal solution (10 cc) of hydrochloric acid, and diluted with acetone (100 cc) and ethyl ether (100 cc) and then filtered. The yellow filtrate, after priming, gives rise to the crystallization of a product, which is drained, washed with ethyl ether (2×10 cc) and dried under reduced pressure (5 mm Hg; 0.68 kPa) at 40° C. 10-[(2RS)-1-(1-Pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxylic acid hydrochloride (3.5 g) is thereby obtained in the form of pale yellow crystals, m.p. 215°-217° C.

후처리

  1. temperatureunder reflux
  2. temperatureAfter cooling
  3. customthe yellow solution obtained
  4. filtrationfiltered
  5. customThe yellow filtrate, after priming, gives rise
  6. customto the crystallization of a product, which
  7. washwashed with ethyl ether (2×10 cc)
  8. customdried under reduced pressure (5 mm Hg; 0.68 kPa) at 40° C

출처 및 근거

ORD 기록
ord-6e575cacd2934a42b2707d859b388d67
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04985419

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